Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | BCR | P11274 | 1/20 | 0.64 |
| ▸ | PRKCA | P17252 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | CDK4 | P11802 | 1/20 | 0.59 |
| ▸ | SYK | P43405 | 12/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464407 | 0.84 | SYK (0.59) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL27115765 | 0.84 | CDK2 (0.57) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL7470857 | 0.84 | ABL1 (0.63) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL7471678 | 0.83 | ABL1 (0.64) | ABL1BCRPRKCACDK2SYK | |
| SCHEMBL5734023 | 0.83 | ABL1 (0.64) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL4903508 | 0.83 | ABL1 (0.67) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL5732656 | 0.83 | AURKA (0.66) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL27115897 | 0.81 | PIK3CG (0.69) | CDK2CDK4SYKPIK3CAPIK3CG | |
| SCHEMBL7468539 | 0.81 | ABL1 (0.71) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL4905854 | 0.80 | ABL1 (0.57) | ABL1BCRPRKCASYKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |