SCHEMBL27118703

SCHEMBL27118703

COc1cc2c(cc1Br)-c1c(c(C(=O)N3CCOCC3(C)C)nn1-c1cc(Cl)cc(Cl)c1)C2

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ GRM5 P41594 2/20 0.38
▸ PIK3CD O00329 13/20 0.37
▸ PIK3R2 O00459 13/20 0.37
▸ PIK3CA P42336 13/20 0.37
▸ PIK3CB P42338 13/20 0.37
▸ PIK3CG P48736 13/20 0.37
▸ PIK3R5 Q8WYR1 13/20 0.37
▸ PIK3R3 Q92569 13/20 0.37
▸ GLA P06280 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ CNR1 P21554 1/20 0.33
▸ CNR2 P34972 1/20 0.33
▸ CA12 O43570 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27119377 0.94 GRM5 (0.38) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL30759592 0.94 GRM5 (0.38) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL30885924 0.88 GRM5 (0.37) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL27117858 0.88 GRM5 (0.38) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL31236983 0.88 GRM5 (0.38) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL31236950 0.88 GRM5 (0.37) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL30759571 0.88 GRM5 (0.38) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL27118795 0.87 GRM5 (0.37) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL30759519 0.87 GRM5 (0.36) GRM5PIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL27118043 0.87 GRM5 (0.36) GRM5PIK3CDPIK3R2PIK3CAPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF GEDEON RICHTER PLC (HU) 2026-01-08 — — US disclosed
EP-4577206-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF Celmatix Inc. (US) 2025-07-02 — — EP disclosed
WO-2024044778-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-02-29 — — WO disclosed
WO-2024044778-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-02-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF FSHR, GNRHR, LHCGR GRM5 222/4885PIK3CD 2697/4885PIK3R2 1155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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