Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712974 | 0.91 | PIK3CD (0.49) | PIK3CDL3MBTL1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL2711897 | 0.82 | PIK3CD (0.54) | PIK3CDL3MBTL1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL2712834 | 0.81 | PIK3CD (0.52) | PIK3CDL3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL2713104 | 0.80 | PIK3CD (0.62) | PIK3CDMAPTLMNAPIK3CA | |
| SCHEMBL2713223 | 0.76 | PIK3CD (0.75) | PIK3CDPIK3CA | |
| SCHEMBL3774912 | 0.73 | PIK3CD (0.59) | PIK3CDPIK3CA | |
| SCHEMBL2711475 | 0.71 | ALDH1A1 (0.58) | L3MBTL1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL2712521 | 0.71 | PIK3CD (0.51) | PIK3CDL3MBTL1MAPTCYP3A4PIK3CA | |
| SCHEMBL2712519 | 0.70 | PIK3CD (0.72) | PIK3CDPIK3CA | |
| SCHEMBL2711628 | 0.70 | PIK3CD (0.74) | PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445886-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |