Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 4/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LAP3 | P28838 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27032750 | 1.00 | SLC7A5 (0.50) | SLC7A5MMEFOLH1ALDH1A1MAPT | |
| SCHEMBL31129134 | 0.87 | SLC7A5 (0.50) | SLC7A5MMEFOLH1ALDH1A1MAPT | |
| SCHEMBL8496218 | 0.87 | SLC7A5 (0.50) | SLC7A5MMEFOLH1ALDH1A1MAPT | |
| SCHEMBL8945304 | 0.86 | MME (0.61) | SLC7A5MMEALDH1A1MAPTLAP3 | |
| SCHEMBL8945299 | 0.86 | MME (0.61) | SLC7A5MMEALDH1A1MAPTLAP3 | |
| SCHEMBL30600472 | 0.86 | MME (0.61) | SLC7A5MMEALDH1A1MAPTLAP3 | |
| Leu-Leu SCHEMBL29401942 | 0.86 | ALDH1A1 (0.60) | SLC7A5MMEFOLH1ALDH1A1MAPT | |
| Leu-Leu SCHEMBL235250 | 0.86 | ALDH1A1 (0.60) | SLC7A5MMEFOLH1ALDH1A1MAPT | |
| Leu-Leu SCHEMBL235249 | 0.86 | ALDH1A1 (0.60) | SLC7A5MMEFOLH1ALDH1A1MAPT | |
| Leu-Leu SCHEMBL13737576 | 0.86 | ALDH1A1 (0.60) | SLC7A5MMEFOLH1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |