Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.41 |
| ▸ | BCHE | P06276 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712715 | 0.81 | KDM4E (0.44) | ACHEALDH1A1PKMPOLBKDM4E | |
| SCHEMBL1400633 | 0.79 | KHK (0.48) | ACHEBCHEALDH1A1PKMKHK | |
| SCHEMBL1936227 | 0.77 | ACHE (0.52) | ACHEBCHEALDH1A1KDM4EHPGD | |
| SCHEMBL1936228 | 0.77 | ACHE (0.52) | ACHEBCHEALDH1A1KDM4EHPGD | |
| SCHEMBL14911567 | 0.76 | KHK (0.44) | ACHEBCHEALDH1A1KHKPOLB | |
| SCHEMBL2713294 | 0.73 | KHK (0.36) | ACHEBCHEKHKPOLBJAK2 | |
| SCHEMBL14923677 | 0.72 | KHK (0.55) | ACHEBCHEALDH1A1PKMKHK | |
| SCHEMBL14927613 | 0.71 | KHK (0.50) | ACHEBCHEALDH1A1PKMKHK | |
| SCHEMBL1936985 | 0.71 | ACHE (0.40) | ACHEBCHEKHKJAK2JAK3 | |
| SCHEMBL1936984 | 0.71 | ACHE (0.40) | ACHEBCHEKHKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |