Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.42 |
| ▸ | JAK2 | O60674 | 11/20 | 0.42 |
| ▸ | JAK1 | P23458 | 10/20 | 0.42 |
| ▸ | TYK2 | P29597 | 10/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713024 | 0.82 | JAK3 (0.38) | JAK3JAK2JAK1TYK2MAP4K4 | |
| SCHEMBL2694742 | 0.77 | JAK3 (0.48) | JAK3JAK2JAK1TYK2MAP4K4 | |
| SCHEMBL2696791 | 0.76 | JAK3 (0.48) | JAK3JAK2JAK1TYK2MAP4K4 | |
| SCHEMBL2697251 | 0.73 | JAK3 (0.46) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL2695389 | 0.72 | JAK3 (0.53) | JAK3JAK2JAK1TYK2MAP4K4 | |
| SCHEMBL2696203 | 0.72 | JAK3 (0.50) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL2695863 | 0.70 | JAK3 (0.48) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL2696548 | 0.70 | VNN1 (0.45) | JAK3JAK2JAK1TYK2MAP4K4 | |
| SCHEMBL4404194 | 0.69 | STAT6 (0.50) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL2693554 | 0.69 | JAK3 (0.65) | JAK3JAK2JAK1TYK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |