Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | SYK | P43405 | 5/20 | 0.38 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
| ▸ | JAK1 | P23458 | 8/20 | 0.36 |
| ▸ | TYK2 | P29597 | 8/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713346 | 0.82 | JAK3 (0.42) | JAK3IRAK4SYKJAK2JAK1 | |
| SCHEMBL2713025 | 0.77 | JAK3 (0.46) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2712360 | 0.76 | SYK (0.45) | JAK3IRAK4SYKJAK2JAK1 | |
| SCHEMBL2712356 | 0.73 | JAK3 (0.46) | JAK3IRAK4SYKJAK2JAK1 | |
| SCHEMBL2713777 | 0.72 | SYK (0.44) | JAK3IRAK4SYKJAK2JAK1 | |
| SCHEMBL2713612 | 0.71 | MAPK10 (0.55) | SYK | |
| SCHEMBL2713978 | 0.71 | SYK (0.54) | SYK | |
| SCHEMBL2713930 | 0.71 | OPRM1 (0.39) | JAK3IRAK4SYKJAK2JAK1 | |
| SCHEMBL2715553 | 0.70 | SYK (0.49) | JAK3IRAK4SYKJAK2JAK1 | |
| SCHEMBL2714357 | 0.70 | SYK (0.54) | JAK3IRAK4SYKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |