Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895758 | 0.83 | KDM4E (0.49) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL2005694 | 0.78 | MAPT (0.45) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL27915701 | 0.77 | EGLN1 (0.47) | PHGDHIRAK4 | |
| SCHEMBL26522667 | 0.76 | TDO2 (0.44) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL15330702 | 0.75 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL16547474 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL12075244 | 0.73 | EPHX2 (0.45) | ALDH1A1SMN1; SMN2MAPTL3MBTL1PDE10A | |
| SCHEMBL15293909 | 0.72 | CYP17A1 (0.43) | SMN1; SMN2MAPTL3MBTL1CYP17A1PDE10A | |
| SCHEMBL7221759 | 0.71 | IRAK4 (0.38) | CYP17A1GRIN2BIRAK4GABRA1GABRG2 | |
| SCHEMBL15293912 | 0.71 | KDM4E (0.42) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |