Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712558 | 0.81 | LMNA (0.67) | AURKARPS6KB1EGFRDYRK1AMEN1 | |
| SCHEMBL15273200 | 0.80 | GAA (0.57) | AURKARPS6KB1EGFRDYRK1AERBB2 | |
| SCHEMBL2713764 | 0.78 | NPC1 (0.51) | EGFRMEN1LMNAMAPTKMT2A | |
| SCHEMBL2714675 | 0.76 | LMNA (0.45) | AURKALMNAMAPTGRM4JAK2 | |
| SCHEMBL2714061 | 0.74 | MEN1 (0.53) | AURKARPS6KB1EGFRMEN1LMNA | |
| SCHEMBL2714067 | 0.74 | AURKA (0.57) | AURKARPS6KB1EGFRDYRK1AERBB2 | |
| SCHEMBL2713518 | 0.73 | NPSR1 (0.47) | LMNAMAPTGRM4BRAF | |
| SCHEMBL15272959 | 0.71 | GRM4 (0.42) | AURKARPS6KB1EGFRDYRK1AMEN1 | |
| SCHEMBL7120632 | 0.71 | EGFR (0.76) | AURKARPS6KB1EGFRDYRK1AERBB2 | |
| SCHEMBL4738590 | 0.70 | EGFR (0.64) | AURKARPS6KB1EGFRERBB2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |