Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712558 | 0.81 | LMNA (0.67) | AURKARPS6KB1GRM4JAK2JAK1 | |
| SCHEMBL14908623 | 0.78 | AURKA (0.51) | AURKARPS6KB1JAK2JAK1DYRK1A | |
| SCHEMBL4560491 | 0.75 | SYK (0.59) | DYRK1AKMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL2713766 | 0.75 | SYK (0.56) | GRM4EGFRMEN1KMT2AALDH1A1 | |
| SCHEMBL2714676 | 0.75 | LMNA (0.46) | GRM4JAK2JAK1XDHSLC22A12 | |
| SCHEMBL2716410 | 0.74 | SYK (0.54) | GRM4EGFRMEN1KMT2AMAPK1 | |
| SCHEMBL2714064 | 0.74 | AURKA (0.54) | AURKARPS6KB1GRM4JAK2JAK1 | |
| SCHEMBL9901562 | 0.73 | DYRK1A (0.61) | AURKARPS6KB1DYRK1AEGFRMEN1 | |
| SCHEMBL2712559 | 0.73 | PTGS1 (0.56) | AURKARPS6KB1JAK2JAK1MEN1 | |
| SCHEMBL9109025 | 0.73 | SYK (0.52) | AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |