Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014702 | 0.91 | NCF1 (0.50) | MAPTKDM4EPOLBCYP3A4ALDH1A1 | |
| SCHEMBL1248587 | 0.79 | MAPT (0.58) | MAPTKDM4EPOLBCYP3A4NCOA1 | |
| SCHEMBL13859959 | 0.78 | MAPT (0.71) | MAPTKDM4EPOLBCYP3A4NCOA1 | |
| SCHEMBL217044 | 0.76 | MAPT (1.00) | MAPTKDM4EPOLBCYP3A4NCOA1 | |
| SCHEMBL2877514 | 0.76 | CYP3A4 (0.54) | MAPTKDM4ECYP3A4LMNAHIF1A | |
| SCHEMBL30183455 | 0.76 | CYP3A4 (0.54) | MAPTKDM4ECYP3A4LMNAHIF1A | |
| SCHEMBL11299370 | 0.76 | KDM4E (0.42) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL276609 | 0.74 | MAPT (0.58) | MAPTKDM4EPOLBCYP3A4NCOA1 | |
| SCHEMBL428159 | 0.74 | MAPT (0.58) | MAPTKDM4EPOLBCYP3A4LMNA | |
| SCHEMBL29662059 | 0.74 | MAPT (0.58) | MAPTKDM4EPOLBCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052451-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-04-26 | — | — | WO | claimed |
| WO-2012052451-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-04-26 | — | — | WO | disclosed |