Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32679673 | 1.00 | TDP1 (0.48) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL30600 | 0.91 | TDP1 (0.55) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL15960323 | 0.88 | TRPA1 (0.43) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL29382225 | 0.85 | TSHR (0.50) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL28289 | 0.85 | TSHR (0.50) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL27010 | 0.84 | TDP1 (0.39) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL28791116 | 0.81 | TDP1 (0.46) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL7890770 | 0.79 | TSHR (0.36) | TDP1TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL7564051 | 0.79 | HTR1A (0.39) | TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL17355120 | 0.79 | TDP1 (0.44) | TDP1TRPA1ALDH1A1TSHRTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336717-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, LLC (US) | 2019-07-02 | — | — | US | disclosed |
| WO-2017185324-A1 | GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN OLEFIN DISPROPORTIONATION REACTIONS | XIA, LING (CN) | 2017-11-02 | — | — | WO | disclosed |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, LLC | 2016-09-22 | — | — | US | disclosed |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, LLC | 2016-09-22 | — | — | US | disclosed |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, LLC | 2016-09-22 | — | — | US | disclosed |
| EP-2406240-B1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS INC (US) | 2015-12-23 | — | — | EP | disclosed |
| EP-2406240-B1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS INC (US) | 2015-12-23 | — | — | EP | disclosed |
| US-9212153-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212153-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| EP-2801570-A1 | Inhibitors of beta-secretase | Vitae Pharmaceuticals, Inc. (US) | 2014-11-12 | — | — | EP | disclosed |
| WO-1993005772-A1 | φ-[2-(PHOSPHONOALKYL)PHENYL]-2-AMINOALKANOIC ACIDS AS ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | NOVA PHARMACEUTICAL CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| US-4824977-A | HYDROFORMYLATION | EASTMAN KODAK COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| US-4774362-A | HYDROFORMYLATION CATALYSTS FOR REACTION OF OLEFINS | EASTMANK KODAK COMPANY (US) | 1988-09-27 | — | — | US | disclosed |
| US-4761405-A | Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency | NOVA PHARMACEUTICAL CORPORATION (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0275639-A1 | N-substituted cyclic amides, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-07-27 | — | — | EP | disclosed |
| EP-0242709-A2 | Antagonists of specific excitatory amino acid neurotransmitter receptors | NOVA PHARMACEUTICAL CORPORATION (US) | 1987-10-28 | — | — | EP | disclosed |
| WO-1987006131-A1 | ANTAGONISTS OF SPECIFIC EXCITATORY AMINO ACID NEUROTRANSMITTER RECEPTORS | RZESZOTARSKI JANUSZ WACLAW (US) | 1987-10-22 | — | — | WO | disclosed |
| US-4657899-A | ANALGESICS, COGNITION ACTIVATORS | NOVA PHARMACEUTICAL CORPORATION (US) | 1987-04-14 | — | — | US | disclosed |
| US-3960858-A | 3-Hetero acyl-2,3-benzoxazepines | GRUPPO LEPETIT S.P.A. (IT) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336717-B2 | Inhibitors of beta-secretase | BACE1, BACE2, PSEN1 | TDP1 582/4885TRPA1 4025/4885ALDH1A1 2962/4885 |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | BACE1, BACE2, PSEN1 | TDP1 582/4885TRPA1 4025/4885ALDH1A1 2962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.