Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037678 | 0.88 | MET (0.59) | ALDH1A1GAAMEN1KMT2AMAPT | |
| SCHEMBL28939777 | 0.85 | SLC22A6 (0.49) | SLC22A6GPR84IMPDH2CYP2A6ATM | |
| SCHEMBL5513343 | 0.83 | SLC22A6 (0.47) | SLC22A6GPR84IMPDH2CYP2A6ATM | |
| SCHEMBL29557960 | 0.83 | PBRM1 (0.52) | SLC22A6GPR84IMPDH2CYP2A6ATM | |
| SCHEMBL15415994 | 0.83 | PBRM1 (0.52) | SLC22A6GPR84IMPDH2CYP2A6ATM | |
| SCHEMBL32896 | 0.83 | CYP3A4 (0.48) | SLC22A6GPR84IMPDH2CYP2A6ATM | |
| SCHEMBL517162 | 0.83 | SLC22A6 (0.47) | SLC22A6GPR84IMPDH2CYP2A6ATM | |
| SCHEMBL329511 | 0.83 | SLC22A6 (0.56) | SLC22A6GPR84IMPDH2CYP2A6ATM | |
| SCHEMBL28406584 | 0.82 | POLB (0.53) | ALDH1A1GAAMEN1KMT2ACYP3A4 | |
| SCHEMBL28246139 | 0.82 | MEN1 (0.62) | GAAMEN1KMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217971-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-07-04 | — | — | US | disclosed |
| US-20240140945-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-05-02 | — | — | US | disclosed |
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| CN-117177973-A | Pyrido [3,2-D ] pyrimidine compounds and their use for the treatment of proliferative disorders | 蒙特利尔大学 | 2023-12-05 | — | — | CN | disclosed |
| CN-103923067-B | The micromolecular inhibitor of a kind of MdmX/Mdm2 and preparation method and application | 湖北工业大学 | 2016-08-24 | — | — | CN | disclosed |
| CN-103923067-A | Small-molecule inhibitor of Mdm<X>/Mdm<2>, as well as preparation method and applications | UNIV HUBEI TECHNOLOGY | 2014-07-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240140945-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | BRAF, NRAS, KRAS | SLC22A6 2809/4885GPR84 4009/4885IMPDH2 567/4885 |
| US-20240217971-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | BRAF, NRAS, DPYD | SLC22A6 2755/4885GPR84 3994/4885IMPDH2 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.