Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27148809 | 0.83 | SLC22A6 (0.50) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL28939777 | 0.82 | SLC22A6 (0.49) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL19211701 | 0.80 | EDNRA (0.50) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL517162 | 0.80 | SLC22A6 (0.47) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL329511 | 0.80 | SLC22A6 (0.56) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL15415994 | 0.80 | PBRM1 (0.52) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL5513343 | 0.80 | SLC22A6 (0.47) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL29557960 | 0.80 | PBRM1 (0.52) | CYP3A4GPR84MEN1MAPTAHR | |
| SCHEMBL8479026 | 0.78 | SLC22A6 (0.54) | CYP3A4GPR84MEN1MAPTAHR | |
| Potassium Ion SCHEMBL29053737 | 0.78 | SLC22A6 (0.46) | CYP3A4GPR84MEN1MAPTAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 329 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4298092-B1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-11-26 | — | — | EP | claimed |
| EP-4562003-A1 | NOVEL 7-SUBSTITUTED INDOLE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-04 | — | — | EP | claimed |
| EP-4562004-A1 | NOVEL 7-SUBSTITUTED INDOLE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-04 | — | — | EP | claimed |
| CN-119562950-A | Novel pyrimidinyl and triazinyl sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-119497717-A | Linker, conjugate and uses thereof | 启德医药科技（苏州）有限公司 | 2025-02-21 | — | — | CN | claimed |
| US-12071404-B2 | Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides | UCB PHARMA GMBH (DE) | 2024-08-27 | — | — | US | claimed |
| CN-118251241-A | Antibodies, linkers, supports, conjugates and uses thereof | 启德医药科技（苏州）有限公司 | 2024-06-25 | — | — | CN | claimed |
| WO-2024023129-A1 | NOVEL 7-SUBSTITUTED INDOLE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-01 | — | — | WO | claimed |
| WO-2024023128-A1 | NOVEL 7-SUBSTITUTED INDOLE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-01 | — | — | WO | claimed |
| WO-2024002330-A1 | IMMOBILIZED ENDOGLYCOSIDASE FUSION PROTEIN AND USE THEREOF | 启德医药科技（苏州）有限公司 | 2024-01-04 | — | — | WO | claimed |
| WO-2009068467-A1 | AMINOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | claimed |
| CN-101434571-A | Cycloalkano [1,2-b] indole sulfonic acid amide, and method for synthesizing isomer or salt thereof | HANGZHOU RONGLI MEDICINE TECHN (CN) | 2009-05-20 | — | — | CN | claimed |
| EP-1947085-A1 | Substituted indole sulfonamide compounds, their preparation and use as medicaments | Laboratorios del Dr. Esteve S.A. (ES) | 2008-07-23 | — | — | EP | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| US-5374647-A | Anticoagulants, thromboxane synthase inhibitors | BAYER AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | claimed |
| CN-1070397-A | Dihydropyridine and method for making and medicinal thereof that the indoles sulphonamide replaces | BAYER AG (DE) | 1993-03-31 | — | — | CN | claimed |
| EP-0533014-A1 | Indolesulfonamide substituted dihydropyridines, process for their preparation and drugs containing them | BAYER AG (DE) | 1993-03-24 | — | — | EP | claimed |
| EP-0473024-A1 | Heterocyclic substituted cycloalkano(b)-indolesulfonamides | BAYER AG (DE) | 1992-03-04 | — | — | EP | claimed |
| CN-1015711-B | Cycloalkaho [1,2-b] indole-sulphonamides | BAYER AG (DE) | 1992-03-04 | — | — | CN | claimed |
| US-4965258-A | Anticoagulant; thromboxane a2 antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1990-10-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12071404-B2 | Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides | GPR17, GPR18, GPR27 | CYP3A4 2597/4885GPR84 14/4885MEN1 2601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.