Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.45 |
| ▸ | RXRB | P28702 | 4/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27149405 | 0.85 | KDM4E (0.46) | CAMKK2MAP2K4MAPK1TSHRSGK1 | |
| SCHEMBL8123127 | 0.79 | RXRA (0.44) | RXRARXRBSRD5A2CAMKK2HSD17B10 | |
| SCHEMBL13373959 | 0.71 | NOTUM (0.38) | RXRB | |
| SCHEMBL5183751 | 0.71 | MAP2K4 (0.55) | RXRARXRBRXRGSRD5A2MAP2K4 | |
| SCHEMBL8507165 | 0.69 | MAP2K4 (0.50) | RXRARXRBHSD17B10RARBRARG | |
| SCHEMBL15510700 | 0.69 | KDM4E (0.40) | CAMKK2HSD17B10MAPK1 | |
| SCHEMBL2053275 | 0.66 | SRD5A2 (0.77) | RXRARXRBRXRGSRD5A2NR1H4 | |
| Terephthalic Acid SCHEMBL10332533 | 0.66 | TSHR (0.75) | RXRARXRBRXRGSRD5A2RARB | |
| SCHEMBL1111577 | 0.66 | KDM4E (0.47) | SRD5A2HSD17B10MAP2K4TP53TSHR | |
| SCHEMBL15758954 | 0.66 | ALPL (0.45) | SRD5A2HSD17B10MAP2K4MAPK1MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326714-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022223750-A1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2022-10-27 | — | — | WO | disclosed |