Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | WNT3 | P56703 | 2/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157329 | 0.79 | KMT2A (0.48) | KMT2AMEN1PTGESSFRP1ACKR3 | |
| SCHEMBL17064024 | 0.73 | MEN1 (0.55) | KMT2AMEN1WNT3SFRP1NPC1 | |
| SCHEMBL17064026 | 0.73 | MEN1 (0.55) | KMT2AMEN1WNT3SFRP1NPC1 | |
| SCHEMBL30463745 | 0.71 | MEN1 (0.55) | KMT2AMEN1PTGESNPC1LMNA | |
| SCHEMBL22556375 | 0.71 | MEN1 (0.55) | KMT2AMEN1PTGESNPC1LMNA | |
| SCHEMBL1222596 | 0.70 | POLB (0.56) | SFRP1LMNAALDH1A1 | |
| SCHEMBL4954647 | 0.69 | NPC1 (0.59) | KMT2AMEN1NPC1LMNANPSR1 | |
| SCHEMBL4954654 | 0.69 | NPC1 (0.59) | KMT2AMEN1NPC1LMNANPSR1 | |
| SCHEMBL25933 | 0.68 | POLB (0.58) | KMT2AMEN1 | |
| SCHEMBL28529044 | 0.67 | NPC1 (0.46) | KMT2AMEN1WNT3SFRP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329880-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |