Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1651945 | 0.87 | KMT2A (0.80) | KMT2AKDM4EPKMALDH1A1ABL1 | |
| SCHEMBL27157338 | 0.85 | KMT2A (0.50) | KMT2AUSP30KDM4EPKMALDH1A1 | |
| SCHEMBL3325048 | 0.83 | ALDH1A1 (0.58) | KMT2AUSP30KDM4EPKMALDH1A1 | |
| SCHEMBL969043 | 0.83 | ALDH1A1 (0.58) | KMT2AUSP30KDM4EPKMALDH1A1 | |
| SCHEMBL969044 | 0.83 | ALDH1A1 (0.58) | KMT2AUSP30KDM4EPKMALDH1A1 | |
| SCHEMBL27157329 | 0.83 | KMT2A (0.48) | KMT2AUSP30KDM4EPKMALDH1A1 | |
| SCHEMBL29060740 | 0.83 | KDM4E (0.63) | KMT2AUSP30KDM4EPKMABL1 | |
| SCHEMBL5870918 | 0.83 | ABL1 (0.62) | KMT2AUSP30ALDH1A1HPGDRAB9A | |
| SCHEMBL3715390 | 0.83 | ABL1 (0.62) | KMT2AUSP30ALDH1A1HPGDRAB9A | |
| SCHEMBL30824540 | 0.82 | USP30 (0.53) | KMT2AUSP30KDM4ERAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246952-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2024-07-25 | — | — | US | disclosed |
| CN-117751114-A | Small molecule modulators of glucocerebrosidase activity and uses thereof | 凡况生化公司 | 2024-03-22 | — | — | CN | disclosed |
| EP-4329880-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232360-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2022-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246952-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | GBA1, GAA, GBA2 | KMT2A 3498/4885USP30 2938/4885KDM4E 3762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.