Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 7/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2041556 | 0.85 | GRM5 (0.47) | BACE1PRMT5WDR77ROCK1LPL | |
| SCHEMBL29421580 | 0.85 | GRM5 (0.47) | BACE1PRMT5WDR77ROCK1LPL | |
| SCHEMBL29896800 | 0.82 | BACE1 (0.41) | BACE1PRMT5WDR77ROCK1LPL | |
| SCHEMBL29896931 | 0.82 | KCNH2 (0.42) | PRMT5WDR77ROCK1LPLLIPG | |
| SCHEMBL15796518 | 0.82 | BACE1 (0.41) | BACE1PRMT5WDR77ROCK1LPL | |
| SCHEMBL15796700 | 0.82 | KCNH2 (0.42) | PRMT5WDR77ROCK1LPLLIPG | |
| SCHEMBL28504213 | 0.81 | GRM5 (0.40) | BACE1PRMT5WDR77ROCK1LPL | |
| SCHEMBL30162918 | 0.79 | GRM5 (0.39) | BACE1PRMT5WDR77ROCK1GRM5 | |
| SCHEMBL29218274 | 0.79 | GRM5 (0.39) | BACE1PRMT5WDR77ROCK1GRM5 | |
| SCHEMBL29964419 | 0.79 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330252-A1 | SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |