Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.36 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29962387 | 0.86 | IDO1 (0.42) | IDO1S1PR1S1PR5PRKXIKBKE | |
| SCHEMBL19411886 | 0.85 | IDO1 (0.48) | IDO1S1PR1S1PR5PRKXIKBKE | |
| SCHEMBL27160337 | 0.82 | TEAD1 (0.48) | IDO1LIPGTACR1NAAA | |
| SCHEMBL27160506 | 0.81 | IDO1 (0.39) | IDO1S1PR1S1PR5PRKXIKBKE | |
| SCHEMBL21723019 | 0.79 | IDO1 (0.44) | IDO1S1PR1S1PR5PRKXIKBKE | |
| SCHEMBL27160413 | 0.78 | TEAD1 (0.50) | IDO1S1PR1S1PR5PRKXIKBKE | |
| SCHEMBL23149381 | 0.76 | HCRTR1 (0.43) | IDO1S1PR1S1PR5PRKXIKBKE | |
| SCHEMBL23850577 | 0.76 | ENPP2 (0.43) | IDO1S1PR1S1PR5PRKXIKBKE | |
| SCHEMBL18580674 | 0.74 | AXL (0.42) | S1PR1S1PR5 | |
| SCHEMBL31308833 | 0.74 | IDO1 (0.49) | IDO1S1PR1S1PR5PRKXIKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330253-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |