Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718886 | 0.91 | CNR2 (0.40) | MEN1KMT2ARBP4TRPV1TRPA1 | |
| SCHEMBL2716097 | 0.91 | MEN1 (0.39) | MEN1KMT2ARBP4CNR2HSD17B10 | |
| SCHEMBL2719156 | 0.90 | TRPV1 (0.41) | MEN1KMT2ARBP4TRPV1HSD17B10 | |
| SCHEMBL2715957 | 0.87 | MEN1 (0.42) | MEN1KMT2ARBP4TRPV1CNR2 | |
| SCHEMBL2719728 | 0.86 | MEN1 (0.40) | MEN1KMT2ARBP4TRPV1TRPA1 | |
| SCHEMBL2719095 | 0.85 | PHGDH (0.49) | MEN1KMT2ARBP4TRPV1KDM4E | |
| SCHEMBL2384868 | 0.84 | PDGFRB (0.45) | MEN1KMT2ATRPV1ALDH1A1PDGFRB | |
| SCHEMBL2730160 | 0.83 | TRPV1 (0.45) | MEN1KMT2ARBP4TRPV1TRPA1 | |
| SCHEMBL2385769 | 0.83 | PDGFRB (0.44) | MEN1KMT2ATRPV1HSD17B10PDGFRB | |
| SCHEMBL2384174 | 0.83 | MTNR1B (0.43) | MEN1KMT2ARBP4TRPV1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |