Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6122791 | 0.89 | GRM1 (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGGRM1 | |
| SCHEMBL2716749 | 0.89 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGGRM1 | |
| SCHEMBL2719961 | 0.86 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGGRM1 | |
| SCHEMBL6122677 | 0.82 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGGRM1 | |
| SCHEMBL6122842 | 0.81 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGGRM1 | |
| SCHEMBL6128775 | 0.78 | GRM1 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGGRM1 | |
| SCHEMBL2716683 | 0.77 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL2717090 | 0.76 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGGRM1 | |
| SCHEMBL3781566 | 0.76 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL2716698 | 0.75 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |