Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121716 | 0.86 | CBFB (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAMETAP2 | |
| SCHEMBL2718718 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAMETAP2 | |
| SCHEMBL2716683 | 0.83 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CGPIK3CALMNA | |
| SCHEMBL2716696 | 0.79 | PIK3CD (0.61) | PIK3CDPIK3CBPIK3CGPIK3CAMETAP2 | |
| SCHEMBL2716751 | 0.78 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL2720602 | 0.78 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2720117 | 0.78 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2720107 | 0.77 | PIK3CD (0.57) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2716680 | 0.75 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAMETAP2 | |
| SCHEMBL15320551 | 0.75 | KDM4E (0.47) | PIK3CDMETAP2METAP1CBFBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |