Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28826584 | 0.84 | EPHX1 (0.67) | EPHX1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL1161063 | 0.79 | THRB (0.47) | KMT2ALMNANPSR1ALDH1A1CRHBP | |
| SCHEMBL3183223 | 0.77 | EPHX2 (0.60) | EPHX1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL3183232 | 0.77 | EPHX2 (0.60) | EPHX1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL16064910 | 0.77 | EPHX1 (0.63) | EPHX1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL16064908 | 0.77 | GAA (0.66) | EPHX1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL9948714 | 0.77 | GLA (0.47) | KMT2ALMNANPSR1ALDH1A1CRHBP | |
| SCHEMBL7702219 | 0.75 | GAA (0.69) | EPHX1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL23933291 | 0.75 | EPHX1 (0.53) | EPHX1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL23933261 | 0.75 | EPHX1 (0.53) | EPHX1GAAKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |