Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30054892 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL4985818 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL20422066 | 0.81 | MAPT (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL5880447 | 0.81 | PDE10A (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL5880628 | 0.81 | ALDH1A1 (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL20422061 | 0.80 | MAPT (0.45) | SMN1; SMN2ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL5880430 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL6394632 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL5880545 | 0.77 | ALDH1A1 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL5880470 | 0.77 | ALDH1A1 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240262822-A1 | WDR5 INHIBITORS AND MODULATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-08-08 | — | — | US | disclosed |
| EP-4334305-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236101-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY (US) | 2022-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240262822-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | SMN1; SMN2 2023/4885MEN1 2330/4885KMT2A 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.