Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | S100A4 | P26447 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27168516 | 0.88 | MAPK14 (0.34) | MAPK14TDP1ALDH1A1S100A4KMT2A | |
| SCHEMBL29516860 | 0.78 | S100A4 (0.37) | MAPK14TDP1ALDH1A1S100A4KMT2A | |
| SCHEMBL25529496 | 0.78 | S100A4 (0.37) | MAPK14TDP1ALDH1A1S100A4KMT2A | |
| SCHEMBL27168535 | 0.75 | MAPK14 (0.34) | MAPK14TDP1S100A4KMT2AMAPT | |
| SCHEMBL26162618 | 0.75 | MAPT (0.39) | MAPK14ALDH1A1KMT2AMAPTRECQL | |
| SCHEMBL7159890 | 0.73 | GPR35 (0.54) | TDP1ALDH1A1S100A4KMT2AGPR35 | |
| SCHEMBL26162646 | 0.72 | MAPK14 (0.34) | MAPK14TDP1ALDH1A1S100A4KMT2A | |
| SCHEMBL26162637 | 0.72 | MAPK14 (0.36) | MAPK14TDP1ALDH1A1S100A4KMT2A | |
| SCHEMBL25197753 | 0.72 | IDH2 (0.36) | MAPK14TDP1ALDH1A1RECQLPIK3CD | |
| SCHEMBL29517002 | 0.72 | IDH2 (0.36) | MAPK14TDP1ALDH1A1RECQLPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421217-B2 | Pyrazine derivative or salt thereof, and use of same | FUJIFILM CORPORATION (JP) | 2025-09-23 | — | — | US | disclosed |
| EP-4052760-B1 | PYRAZINE DERIVATIVE OR SALT THEREOF, AND USE OF SAME | FUJIFILM CORP (JP) | 2024-03-13 | — | — | EP | disclosed |
| EP-4052760-A1 | PYRAZINE DERIVATIVE OR SALT THEREOF, AND USE OF SAME | FUJIFILM Corporation (JP) | 2022-09-07 | — | — | EP | disclosed |
| US-20220259185-A1 | PYRAZINE DERIVATIVE OR SALT THEREOF, AND USE OF SAME | FUJIFILM CORPORATION (JP) | 2022-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12421217-B2 | Pyrazine derivative or salt thereof, and use of same | DHODH, IDH1, IDH2 | MAPK14 2456/4885TDP1 1422/4885ALDH1A1 117/4885 |
| US-20220259185-A1 | PYRAZINE DERIVATIVE OR SALT THEREOF, AND USE OF SAME | DHODH, IDH1, IDH2 | MAPK14 2456/4885TDP1 1422/4885ALDH1A1 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.