Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | AHR | P35869 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717394 | 0.95 | RAB9A (0.59) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL3959565 | 0.84 | RAB9A (0.54) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL2715878 | 0.81 | RAB9A (0.63) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL2716637 | 0.81 | NPC1 (0.63) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL2714517 | 0.80 | MAPT (0.65) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL29421237 | 0.80 | MAPT (0.65) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL29421217 | 0.80 | RAB9A (0.73) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL2717012 | 0.79 | MAPK9 (0.51) | IMPDH2MAPK9MAPK10ROCK2ROCK1 | |
| SCHEMBL4435114 | 0.78 | KDR (0.65) | MAPTRAB9ANPC1SMN1; SMN2AHR | |
| SCHEMBL3951396 | 0.78 | MEN1 (0.52) | MAPTRAB9ANPC1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |