Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | AHR | P35869 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | DHODH | Q02127 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714517 | 1.00 | MAPT (0.65) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL10644254 | 0.86 | DHODH (0.77) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL479805 | 0.86 | DHODH (0.76) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL29421217 | 0.84 | RAB9A (0.73) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL10642215 | 0.82 | KDM4E (0.56) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL2713370 | 0.82 | LMNA (0.72) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL2717394 | 0.80 | RAB9A (0.59) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL2717010 | 0.80 | MAPT (0.59) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL28282946 | 0.79 | LMNA (0.73) | MAPTRAB9ASMN1; SMN2NPC1AHR | |
| SCHEMBL3959565 | 0.79 | RAB9A (0.54) | MAPTRAB9ASMN1; SMN2NPC1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114149409-A | (hetero) aryl amide compound with protein kinase inhibitory activity | 中国药科大学 | 2022-03-08 | — | — | CN | disclosed |