Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 10/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 9/20 | 0.45 |
| ▸ | BRD1 | O95696 | 8/20 | 0.45 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30868516 | 1.00 | TRIM24 (0.45) | TRIM24BRPF1BRD1BRPF3KMT2A | |
| SCHEMBL24631270 | 0.82 | TRPA1 (0.44) | BRD4TEAD1YAP1 | |
| SCHEMBL30868611 | 0.82 | TRPA1 (0.44) | BRD4TEAD1YAP1 | |
| SCHEMBL30868535 | 0.82 | BRAF (0.45) | KMT2ABRD4TEAD1YAP1PKM | |
| SCHEMBL24631171 | 0.82 | BRAF (0.45) | KMT2ABRD4TEAD1YAP1PKM | |
| SCHEMBL30868598 | 0.78 | TEAD1 (0.42) | KMT2ABRD4TEAD1YAP1SMN1; SMN2 | |
| SCHEMBL24631413 | 0.78 | TEAD1 (0.42) | KMT2ABRD4TEAD1YAP1SMN1; SMN2 | |
| SCHEMBL24631240 | 0.78 | MAPT (0.44) | KMT2AMAPTHPGDBRD4TEAD1 | |
| SCHEMBL24631205 | 0.77 | BRD4 (0.41) | KMT2ABRD4TEAD1YAP1 | |
| SCHEMBL30868548 | 0.77 | BRD4 (0.41) | KMT2ABRD4TEAD1YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | TRIM24 3636/4885BRPF1 2175/4885BRD1 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.