Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718161 | 0.91 | TSHR (0.51) | LCKTSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL25484165 | 0.86 | NPC1 (0.45) | LCKTSHRALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL7691178 | 0.85 | LCK (0.47) | LCKTSHRALDH1A1PI4KB | |
| SCHEMBL13609513 | 0.84 | TSHR (0.41) | LCKTSHRALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL30557261 | 0.84 | TSHR (0.41) | LCKTSHRALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL538349 | 0.78 | LCK (0.63) | LCKTSHRALDH1A1HPGDPI4KB | |
| SCHEMBL2718805 | 0.76 | MEN1 (0.36) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL24434724 | 0.76 | NPC1 (0.55) | LCKPI4KB | |
| SCHEMBL349175 | 0.76 | ALDH1A1 (0.68) | LCKTSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL31214120 | 0.75 | LCK (0.42) | LCKPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635587-A1 | NOVEL 6-ARYLAMINO PYRIDONE CARBOXAMIDE AS MEK INHIBITORS | Centaurus Biopharma Co., Ltd. (CN) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012059041-A1 | NOVEL 6-ARYLAMINO PYRIDONE CARBOXAMIDE AS MEK INHIBITORS | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2012-05-10 | — | — | WO | disclosed |