Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719668 | 0.91 | LMNA (0.47) | ACACBMEN1NPC1GAARAB9A | |
| SCHEMBL2716769 | 0.89 | PIK3CD (0.43) | ACACBCKS1BSKP1SKP2TACR1 | |
| SCHEMBL2717730 | 0.87 | ADORA2A (0.41) | ACACBBCHELMNACKS1BSKP1 | |
| SCHEMBL2720609 | 0.80 | PIK3CD (0.47) | ACACBCKS1BSKP1SKP2TACR1 | |
| SCHEMBL2719173 | 0.80 | PIK3CD (0.47) | ACACBMEN1GAAKMT2ACKS1B | |
| SCHEMBL2719206 | 0.79 | DHODH (0.46) | CKS1BSKP1SKP2NQO2 | |
| SCHEMBL2718145 | 0.79 | TACR3 (0.46) | MEN1GAAKMT2ALMNATACR1 | |
| SCHEMBL2716877 | 0.78 | PIK3CD (0.46) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL2719177 | 0.78 | DHODH (0.50) | LMNACKS1BSKP1SKP2IDO1 | |
| SCHEMBL2717035 | 0.77 | NQO2 (0.41) | ACACBBCHECKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |