Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 2/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717730 | 0.92 | ADORA2A (0.41) | NQO2SCN9AADORA2AADORA1CKS1B | |
| SCHEMBL2719668 | 0.86 | LMNA (0.47) | NQO2CKS1BSKP1SKP2IDO1 | |
| SCHEMBL2719206 | 0.83 | DHODH (0.46) | NQO2CKS1BSKP1SKP2 | |
| SCHEMBL1694879 | 0.78 | NQO2 (0.47) | NQO2SCN9AADORA2ACKS1BSKP1 | |
| SCHEMBL2717033 | 0.78 | CTSK (0.39) | TACR3TACR2CTSSCTSK | |
| SCHEMBL2717152 | 0.77 | ACACB (0.45) | NQO2CKS1BSKP1SKP2IDO1 | |
| SCHEMBL2719177 | 0.76 | DHODH (0.50) | NQO2CKS1BSKP1SKP2IDO1 | |
| SCHEMBL2716769 | 0.75 | PIK3CD (0.43) | NQO2CKS1BSKP1SKP2IDO1 | |
| SCHEMBL2720609 | 0.74 | PIK3CD (0.47) | NQO2CKS1BSKP1SKP2ACACB | |
| SCHEMBL1694905 | 0.74 | NQO2 (0.47) | NQO2SCN9AIDO1BCHEACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |