Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Talazoparib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 20/20 | 0.80 |
| ▸ | PARP2 known ✓ | Q9UGN5 | 15/20 | 0.80 |
| ▸ | PARP3 | Q9Y6F1 | 15/20 | 0.80 |
| ▸ | TNKS | O95271 | 2/20 | 0.80 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.80 |
| ▸ | PARP16 | Q8N5Y8 | 2/20 | 0.80 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.80 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.80 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.80 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.80 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.80 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Talazoparib SCHEMBL14723419 | 1.00 | PARP1 (0.80) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL29363118 | 1.00 | PARP1 (0.80) | PARP1PARP2PARP3TNKSPARP10 | |
| SCHEMBL23998013 | 0.91 | PARP1 (0.90) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL16204525 | 0.90 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL30953898 | 0.90 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL29351841 | 0.90 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL2295997 | 0.90 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL24440571 | 0.90 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL23048317 | 0.90 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 | |
| Talazoparib SCHEMBL2299348 | 0.90 | PARP1 (1.00) | PARP1PARP2PARP3TNKSPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3757106-A1 | CRYSTALINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTALAZIN-3(7H)-ONE TOSYLATE SALT | Medivation Technologies LLC (US) | 2020-12-30 | — | — | EP | claimed |
| US-20140228369-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2014-08-14 | — | — | US | claimed |
| US-8735392-B2 | Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt | BIOMARIN PHARMACEUTICAL INC. (US) | 2014-05-27 | — | — | US | claimed |
| US-20120129865-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-05-24 | — | — | US | claimed |
| EP-3174855-B1 | COFORMER SALTS OF (2S,3S)-METHYL 7-FLUORO-2-(4-FLUOROPHENYL)-3-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-4-OXO-1,2,3,4-TETRAHYDROQUINOLINE-5-CARBOXYLATE AND METHODS OF PREPARING THEM | MEDIVATION TECH LLC (US) | 2023-05-10 | — | — | EP | disclosed |
| US-20210094930-A1 | COFORMER SALTS OF (2S,3S)-METHYL 7-FLUORO-2-(4-FLUOROPHENYL)-3-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-4-OXO-1,2,3,4-TETRAHYDROQUINOLINE-5-CARBOXYLATE AND METHODS OF PREPARING THEM | MEDIVATION TECH LLC (US) | 2021-04-01 | — | — | US | disclosed |
| EP-3757106-A1 | CRYSTALINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTALAZIN-3(7H)-ONE TOSYLATE SALT | Medivation Technologies LLC (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-3757106-A1 | CRYSTALINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTALAZIN-3(7H)-ONE TOSYLATE SALT | Medivation Technologies LLC (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-3757106-A1 | CRYSTALINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTALAZIN-3(7H)-ONE TOSYLATE SALT | Medivation Technologies LLC (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-2630146-B1 | CRYSTALINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTALAZIN-3(7H)-ONE TOSYLATE SALT | MEDIVATION TECH LLC (US) | 2020-07-01 | — | — | EP | disclosed |
| EP-2630146-B1 | CRYSTALINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTALAZIN-3(7H)-ONE TOSYLATE SALT | MEDIVATION TECH LLC (US) | 2020-07-01 | — | — | EP | disclosed |
| US-20190106401-A1 | COFORMER SALTS OF (2S,3S)-METHYL 7-FLUORO-2-(4-FLUOROPHENYL)-3-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-4-OXO-1,2,3,4-TETRAHYDROQUINOLINE-5-CARBOXYLATE AND METHODS OF PREPARING THEM | MEDIVATION TECH LLC (US) | 2019-04-11 | — | — | US | disclosed |
| EP-2630146-A1 | CRYSTALINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTALAZIN-3(7H)-ONE TOSYLATE SALT | BioMarin Pharmaceutical Inc. (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2013028495-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) FOR THE TREATMENT OF MULTIPLE MYELOMA | BIOMARIN PHARMACEUTICAL INC. (US) | 2013-02-28 | — | — | WO | disclosed |
| US-20120129865-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129865-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129865-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-05-24 | — | — | US | disclosed |
| WO-2012054698-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012054698-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012054698-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094930-A1 | COFORMER SALTS OF (2S,3S)-METHYL 7-FLUORO-2-(4-FLUOROPHENYL)-3-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-4-OXO-1,2,3,4-TETRAHYDROQUINOLINE-5-CARBOXYLATE AND METHODS OF PREPARING THEM | SLC16A3, TET3, TET1 | PARP1 865/4885PARP2 977/4885PARP3 807/4885 |
| US-20140228369-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | CA9, TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PARP1 2854/4885PARP2 3798/4885PARP3 4512/4885 |
| US-20190106401-A1 | COFORMER SALTS OF (2S,3S)-METHYL 7-FLUORO-2-(4-FLUOROPHENYL)-3-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-4-OXO-1,2,3,4-TETRAHYDROQUINOLINE-5-CARBOXYLATE AND METHODS OF PREPARING THEM | SLC16A3, CYP4F3, CA3 | PARP1 1165/4885PARP2 1212/4885PARP3 983/4885 |
| US-20120129865-A1 | CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT | CA9, TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PARP1 2854/4885PARP2 3798/4885PARP3 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.