Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.46 |
| ▸ | KCNK4 | Q9NYG8 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30006266 | 1.00 | APP (0.55) | APPSMN1; SMN2KDM4ENPC1MAPT | |
| SCHEMBL30828341 | 0.89 | APP (0.53) | APPSMN1; SMN2KDM4ENPC1MAPT | |
| SCHEMBL23364361 | 0.86 | APP (0.53) | APPSMN1; SMN2KDM4ENPC1MAPT | |
| SCHEMBL29874189 | 0.86 | APP (0.53) | APPSMN1; SMN2KDM4ENPC1MAPT | |
| SCHEMBL27173193 | 0.86 | APP (0.46) | APPSMN1; SMN2KDM4ENPC1MAPT | |
| SCHEMBL28786192 | 0.83 | APP (0.52) | APPSMN1; SMN2KDM4ENPC1MAPT | |
| SCHEMBL26518067 | 0.83 | APP (0.57) | APPMAPTSNCA | |
| SCHEMBL13394576 | 0.81 | APP (0.62) | APPMAPTMEN1KMT2ASULT1A1 | |
| SCHEMBL14450187 | 0.81 | APP (0.67) | APPMAPTMEN1KMT2ASULT1A1 | |
| SCHEMBL29453199 | 0.81 | APP (0.76) | APPSMN1; SMN2MAPTSULT1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337259-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | Aprinoia Therapeutics Limited (HK) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022238737-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | APRINOIA THERAPEUTICS LIMITED (CN) | 2022-11-17 | — | — | WO | disclosed |