Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717418 | 0.87 | CBFB (0.44) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL2717145 | 0.87 | CBFB (0.44) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL3805286 | 0.84 | METAP2 (0.46) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL2717695 | 0.82 | CBFB (0.44) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL2717781 | 0.78 | PIK3CD (0.40) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL2717655 | 0.77 | PIK3CD (0.38) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL22238047 | 0.77 | METAP2 (0.49) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL2717528 | 0.76 | PIK3CD (0.45) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL2717476 | 0.74 | PIK3CD (0.56) | CBFBMETAP2METAP1PIK3CDPIK3CG | |
| SCHEMBL20067937 | 0.74 | PIK3CD (0.58) | CBFBMETAP2METAP1PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |