Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719332 | 0.81 | MEN1 (0.44) | MEN1KMT2APFKFB3ARKDM4E | |
| SCHEMBL1695204 | 0.80 | KDM4E (0.35) | MEN1KMT2AKDM4E | |
| SCHEMBL13684949 | 0.71 | KDM4E (0.52) | MEN1KMT2AARKDM4E | |
| SCHEMBL29768864 | 0.70 | MBNL1 (0.42) | MEN1KMT2AARKDM4E | |
| SCHEMBL29768837 | 0.70 | MBNL1 (0.42) | MEN1KMT2AARKDM4E | |
| SCHEMBL3770305 | 0.70 | ESR1 (0.38) | MEN1KMT2AARKDM4E | |
| SCHEMBL2717594 | 0.70 | ESR1 (0.38) | MEN1KMT2AARKDM4E | |
| SCHEMBL3770307 | 0.70 | ESR1 (0.38) | MEN1KMT2AARKDM4E | |
| SCHEMBL28738484 | 0.69 | ALDH1A1 (0.47) | MEN1KMT2A | |
| SCHEMBL21119427 | 0.69 | MEN1 (0.40) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |