Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PDE9A | O76083 | 7/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718597 | 1.00 | SYK (0.48) | SYKGAAGFERMAPTKDM4E | |
| SCHEMBL2729181 | 0.90 | SYK (0.47) | SYKGAAGFERPDE9A | |
| SCHEMBL2729183 | 0.90 | SYK (0.47) | SYKGAAGFERPDE9A | |
| SCHEMBL10271844 | 0.89 | SYK (0.45) | SYKGAAGFER | |
| SCHEMBL2715960 | 0.88 | SYK (0.52) | SYKMAPTPDE9AMEN1KMT2A | |
| SCHEMBL10271846 | 0.88 | SYK (0.40) | SYKMAPTKDM4EMEN1KMT2A | |
| SCHEMBL2730529 | 0.81 | SYK (0.43) | SYKMAPTMEN1KMT2A | |
| SCHEMBL2730531 | 0.81 | SYK (0.43) | SYKMAPTMEN1KMT2A | |
| SCHEMBL10272089 | 0.81 | SYK (0.43) | SYK | |
| SCHEMBL2716538 | 0.81 | SYK (0.50) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |