Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.47 |
| ▸ | PDE9A | O76083 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729183 | 1.00 | SYK (0.47) | SYKPDE9AGAAGFER | |
| SCHEMBL2718602 | 0.90 | SYK (0.48) | SYKPDE9AGAAGFER | |
| SCHEMBL2718597 | 0.90 | SYK (0.48) | SYKPDE9AGAAGFER | |
| SCHEMBL2729448 | 0.90 | SYK (0.44) | SYK | |
| SCHEMBL2729441 | 0.90 | SYK (0.44) | SYK | |
| SCHEMBL2716671 | 0.89 | SYK (0.51) | SYKPDE9A | |
| SCHEMBL2731588 | 0.89 | SYK (0.41) | SYK | |
| SCHEMBL2731593 | 0.89 | SYK (0.41) | SYK | |
| SCHEMBL2716675 | 0.89 | SYK (0.51) | SYKPDE9A | |
| SCHEMBL2729610 | 0.89 | SYK (0.44) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |