⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29089183 | 1.00 | — | — | |
| SCHEMBL23019171 | 1.00 | — | — | |
| SCHEMBL11774866 | 0.78 | LMNA (0.35) | — | |
| SCHEMBL9523940 | 0.77 | — | — | |
| SCHEMBL3818445 | 0.77 | — | — | |
| SCHEMBL3868009 | 0.75 | — | — | |
| SCHEMBL372686 | 0.75 | — | — | |
| SCHEMBL372687 | 0.75 | — | — | |
| SCHEMBL300789 | 0.75 | — | — | |
| SCHEMBL16542404 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445866-A2 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | Shire LLC (US) | 2012-05-02 | — | — | EP | claimed |
| US-20110028552-A1 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | SHIRE LLC | 2011-02-03 | — | — | US | claimed |
| WO-2010149760-A2 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | SHIRE LLC (US) | 2010-12-29 | — | — | WO | claimed |
| EP-3661938-B1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RES GMBH (DE) | 2025-01-15 | — | — | EP | disclosed |
| US-11926631-B2 | Method of treating cancer using amanitin derivatives | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2024-03-12 | — | — | US | disclosed |
| US-20220274995-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2022-09-01 | — | — | US | disclosed |
| US-11420971-B2 | Method for synthesizing amanitins | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2022-08-23 | — | — | US | disclosed |
| EP-2940008-A1 | NOVEL BENZAZEPINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Sanwa Kagaku Kenkyusho Co., Ltd (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-20120196933-A1 | MEXILETINE PRODRUGS | FRANKLIN RICHARD (GB) | 2012-08-02 | — | — | US | disclosed |