Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718864 | 0.81 | SYK (0.44) | SYKLMNA | |
| SCHEMBL2720146 | 0.81 | SYK (0.44) | SYKLMNA | |
| SCHEMBL2716914 | 0.79 | EGFR (0.38) | SYK | |
| SCHEMBL2716917 | 0.79 | EGFR (0.38) | SYK | |
| SCHEMBL2715944 | 0.77 | SYK (0.46) | SYK | |
| SCHEMBL2715948 | 0.77 | SYK (0.46) | SYK | |
| SCHEMBL2715679 | 0.75 | SYK (0.39) | SYK | |
| SCHEMBL2719271 | 0.73 | SYK (0.48) | SYK | |
| SCHEMBL2717463 | 0.72 | SYK (0.48) | SYK | |
| SCHEMBL2717620 | 0.72 | SYK (0.43) | SYKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |