Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718864 | 1.00 | SYK (0.44) | SYKPIP4K2ALMNA | |
| SCHEMBL2717624 | 0.91 | SYK (0.43) | SYKPIP4K2ALMNA | |
| SCHEMBL2717620 | 0.91 | SYK (0.43) | SYKPIP4K2ALMNA | |
| SCHEMBL10272160 | 0.86 | SYK (0.44) | SYK | |
| SCHEMBL2716538 | 0.83 | SYK (0.50) | SYK | |
| SCHEMBL10272086 | 0.83 | SYK (0.49) | SYK | |
| SCHEMBL10272161 | 0.82 | SYK (0.64) | SYK | |
| SCHEMBL2718751 | 0.81 | SYK (0.37) | SYKLMNA | |
| SCHEMBL2715960 | 0.81 | SYK (0.52) | SYK | |
| SCHEMBL2728825 | 0.80 | SYK (0.63) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130317029-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-11-28 | — | — | US | claimed |
| US-20130317029-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-11-28 | — | — | US | disclosed |
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130317029-A1 | OXYPYRIMIDINES AS SYK MODULATORS | SYK, BTK, FYN | SYK 1/4885PIP4K2A 286/4885LMNA 4746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.