Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 4/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713980 | 1.00 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL27188918 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL29597471 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL27188924 | 0.80 | L3MBTL1 (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL27188923 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL22792662 | 0.75 | STS (0.47) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL3958079 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EALDH1A1CA1CA2 | |
| SCHEMBL28910708 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL28547728 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL10341535 | 0.72 | SMN1; SMN2 (0.52) | SMN1; SMN2KDM4EALDH1A1HPGDCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952335-B2 | Process for preparing 1-indanone compounds by intramolecular Friedel-Crafts reaction of alpha,alpha-dialkylmalonate derivatives | FIRMENICH SA (CH) | 2024-04-09 | — | — | US | claimed |
| US-20220356143-A1 | PROCESS FOR PREPARING 1-INDANONE COMPOUNDS BY INTRAMOLECULAR FRIEDEL-CRAFTS REACTION OF ALPHA,ALPHA-DIALKYLMALONATE DERIVATIVES | FIRMENICH SA (CH) | 2022-11-10 | — | — | US | claimed |
| CN-114514219-A | Process for the preparation of 1-indanone compounds by intramolecular friedel-crafts reaction of derivatives of α, α -dialkyl malonates | 弗门尼舍有限公司 | 2022-05-17 | — | — | CN | claimed |
| EP-4013738-B1 | PROCESS FOR PREPARING 1-INDANONE COMPOUNDS BY INTRAMOLECULAR FRIEDEL-CRAFTS REACTION OF ALPHA,ALPHA-DIALKYLMALONATE DERIVATIVES | FIRMENICH & CIE (CH) | 2026-02-25 | — | — | EP | disclosed |
| US-11952335-B2 | Process for preparing 1-indanone compounds by intramolecular Friedel-Crafts reaction of alpha,alpha-dialkylmalonate derivatives | FIRMENICH SA (CH) | 2024-04-09 | — | — | US | disclosed |
| US-20220356143-A1 | PROCESS FOR PREPARING 1-INDANONE COMPOUNDS BY INTRAMOLECULAR FRIEDEL-CRAFTS REACTION OF ALPHA,ALPHA-DIALKYLMALONATE DERIVATIVES | FIRMENICH SA (CH) | 2022-11-10 | — | — | US | disclosed |
| CN-114514219-A | Process for the preparation of 1-indanone compounds by intramolecular friedel-crafts reaction of derivatives of α, α -dialkyl malonates | 弗门尼舍有限公司 | 2022-05-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11952335-B2 | Process for preparing 1-indanone compounds by intramolecular Friedel-Crafts reaction of alpha,alpha-dialkylmalonate derivatives | IP6K1, FDFT1, MINK1 | SMN1; SMN2 4384/4885KDM4E 2392/4885ALDH1A1 149/4885 |
| US-20220356143-A1 | PROCESS FOR PREPARING 1-INDANONE COMPOUNDS BY INTRAMOLECULAR FRIEDEL-CRAFTS REACTION OF ALPHA,ALPHA-DIALKYLMALONATE DERIVATIVES | IP6K1, FDFT1, MINK1 | SMN1; SMN2 4384/4885KDM4E 2392/4885ALDH1A1 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.