Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728249 | 0.94 | SYK (0.53) | SYKALK | |
| SCHEMBL2716442 | 0.91 | SYK (0.60) | SYK | |
| SCHEMBL2729750 | 0.90 | SYK (0.61) | SYK | |
| SCHEMBL10272211 | 0.87 | SYK (0.49) | SYKALKMEN1MAPTKMT2A | |
| SCHEMBL10272209 | 0.74 | CDK7 (0.44) | SYKALKMEN1MAPTKMT2A | |
| SCHEMBL10271845 | 0.73 | SYK (0.41) | SYKMEN1MAPTKMT2A | |
| SCHEMBL736081 | 0.72 | SYK (1.00) | SYK | |
| SCHEMBL2717457 | 0.71 | SYK (0.72) | SYKALK | |
| SCHEMBL2718800 | 0.69 | SYK (0.69) | SYKALK | |
| SCHEMBL2716069 | 0.69 | SYK (0.56) | SYKALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |