Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | CCNH | P51946 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 5/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.44 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272211 | 0.83 | SYK (0.49) | MAPTMEN1KMT2AALKSYK | |
| SCHEMBL10271843 | 0.75 | GAA (0.43) | MAPTMEN1KMT2AGAAKDM4E | |
| SCHEMBL2719026 | 0.74 | SYK (0.57) | MAPTMEN1KMT2AALKSYK | |
| SCHEMBL10272210 | 0.73 | CA2 (0.53) | CDK2MEN1KMT2ACCNA2CCNA1 | |
| SCHEMBL2716442 | 0.70 | SYK (0.60) | SYK | |
| SCHEMBL2728249 | 0.70 | SYK (0.53) | ALKSYK | |
| SCHEMBL4381741 | 0.69 | EGFR (0.51) | CDK7FLT3CDK2CCNE1MAPT | |
| SCHEMBL2729750 | 0.69 | SYK (0.61) | SYK | |
| SCHEMBL760647 | 0.67 | SYK (0.76) | SYK | |
| SCHEMBL10272163 | 0.67 | GAA (0.56) | MAPTMEN1KMT2AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |