Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 10/20 | 0.64 |
| ▸ | F13A1 | P00488 | 7/20 | 0.64 |
| ▸ | TGM1 | P22735 | 4/20 | 0.64 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684972 | 0.89 | TGM2 (0.69) | TGM2F13A1TGM1GPR119PKM | |
| SCHEMBL18410584 | 0.88 | TGM2 (0.65) | TGM2F13A1TGM1PKMPOLB | |
| SCHEMBL1181084 | 0.86 | PKM (0.73) | TGM2F13A1TGM1PKM | |
| SCHEMBL29060791 | 0.86 | TGM2 (0.64) | TGM2F13A1TGM1PKMPOLB | |
| SCHEMBL710366 | 0.86 | TGM2 (0.64) | TGM2F13A1TGM1PKM | |
| SCHEMBL3910274 | 0.86 | TGM2 (0.64) | TGM2F13A1TGM1GPR119PKM | |
| SCHEMBL5253160 | 0.86 | POLB (0.70) | TGM2F13A1TGM1POLBSTS | |
| SCHEMBL2252120 | 0.86 | TGM2 (0.63) | TGM2F13A1TGM1GPR119 | |
| SCHEMBL1253831 | 0.85 | TGM2 (0.63) | TGM2F13A1TGM1GPR119PKM | |
| SCHEMBL18153290 | 0.85 | PKM (0.66) | TGM2F13A1TGM1PKMSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596059-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS DUAL ATX/CA INHIBITORS | HOFFMANN LA ROCHE (CH) | 2024-04-24 | — | — | EP | disclosed |
| CN-110392679-B | Heterocyclic compounds useful as dual ATX/CA inhibitors | 豪夫迈·罗氏有限公司 | 2023-04-07 | — | — | CN | disclosed |