Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30834072 | 1.00 | CLK1 (0.55) | CLK1PIK3CAGSK3BDYRK3CLK2 | |
| SCHEMBL10213915 | 0.79 | JAK2 (0.61) | CLK1PIK3CAGSK3BDYRK3CLK2 | |
| SCHEMBL28592607 | 0.78 | MAPKAPK2 (0.53) | CLK1PIK3CAGSK3BDYRK3CLK2 | |
| SCHEMBL25452980 | 0.76 | TRPA1 (0.55) | CLK1PIK3CAGSK3BDYRK3CLK2 | |
| SCHEMBL25171720 | 0.75 | TRPA1 (0.58) | CLK1GSK3BDYRK3CLK2CDK5 | |
| SCHEMBL30834158 | 0.74 | MAP4K4 (0.41) | GSK3BCLK2CDK5DYRK1ACLK4 | |
| SCHEMBL27201388 | 0.74 | KDM4E (0.40) | AURKBJAK2KDRROCK1KDM4E | |
| SCHEMBL27201289 | 0.74 | MAP4K4 (0.41) | GSK3BCLK2CDK5DYRK1ACLK4 | |
| SCHEMBL30834093 | 0.74 | KDM4E (0.40) | AURKBJAK2KDRROCK1KDM4E | |
| SCHEMBL25452209 | 0.74 | GSK3B (0.60) | CLK1PIK3CAGSK3BDYRK3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-04-25 | — | — | US | claimed |
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | GID4, MDM2, XIAP | CLK1 1452/4885PIK3CA 990/4885GSK3B 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.