Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | FABP1 | P07148 | 1/20 | 0.56 |
| ▸ | FABP6 | P51161 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.53 |
| ▸ | TSHR | P16473 | 6/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27909931 | 0.82 | HDAC3 (0.58) | SMN1; SMN2CYP1A2CYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL5868200 | 0.80 | CYP1A2 (0.56) | CYP1A2CYP2D6CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL2719343 | 0.80 | ALDH1A1 (0.58) | CYP1A2CYP2D6CYP3A4ALDH1A1CYP2C19 | |
| SCHEMBL15069620 | 0.76 | CXCR4 (0.58) | CXCR4POLBFABP1FABP6CYP1A2 | |
| SCHEMBL4778498 | 0.76 | CYP1A2 (0.47) | SMN1; SMN2CYP1A2CYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL17997542 | 0.75 | CHRM2 (0.51) | ESR1POLBSTAT3SMN1; SMN2ESR2 | |
| SCHEMBL3452402 | 0.74 | CYP1A2 (0.66) | SMN1; SMN2CYP1A2CYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL2716338 | 0.74 | TSHR (0.51) | POLBSMN1; SMN2CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL29351380 | 0.74 | CXCR4 (1.00) | CXCR4FABP1FABP6CYP1A2ALDH1A1 | |
| SCHEMBL589266 | 0.74 | CXCR4 (1.00) | CXCR4FABP1FABP6CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470407-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2024-01-24 | — | — | EP | disclosed |
| US-10953007-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2021-03-23 | — | — | US | disclosed |
| EP-3470407-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-2635572-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-10-17 | — | — | EP | disclosed |
| US-20180289704-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2018-10-11 | — | — | US | disclosed |
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | Seaomyx, Inc. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20160317532-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2016-11-03 | — | — | US | disclosed |
| US-9394287-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20130324557-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2013-12-05 | — | — | US | disclosed |
| EP-2635572-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| CN-103288722-A | High-selectivity synthesis method of secondary amine | UNIV WENZHOU | 2013-09-11 | — | — | CN | disclosed |
| CN-103201279-A | Compounds useful as modulators of TRPM8 | SENOMYX INC | 2013-07-10 | — | — | CN | disclosed |
| WO-2012061698-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012061698-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| EP-0297661-A1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10953007-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPM6 | CXCR4 3758/4885ESR1 3125/4885POLB 4439/4885 |
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPM6 | CXCR4 3758/4885ESR1 3125/4885POLB 4439/4885 |
| US-20160317532-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM6 | CXCR4 3758/4885ESR1 3125/4885POLB 4439/4885 |
| US-20130324557-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM6 | CXCR4 3758/4885ESR1 3125/4885POLB 4439/4885 |
| US-20180289704-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM6 | CXCR4 3758/4885ESR1 3125/4885POLB 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.