SCHEMBL2720183

SCHEMBL2720183

CCN(Cc1cccs1)C(=O)C=Cc1cccc(C#N)c1

nearest known ligand 0.64

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 5/20 0.64
▸ MEN1 O00255 1/20 0.49
▸ USP2 O75604 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ P4HB P07237 8/20 0.48
▸ NPC1 O15118 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ SNCA P37840 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2720179 1.00 TRPM8 (0.64) TRPM8MEN1USP2KMT2AP4HB
SCHEMBL2716656 0.88 TRPM8 (0.75) TRPM8MEN1KMT2ANPC1L3MBTL1
SCHEMBL2716660 0.88 TRPM8 (0.75) TRPM8MEN1KMT2ANPC1L3MBTL1
SCHEMBL30582817 0.84 TRPM8 (0.77) TRPM8NPC1L3MBTL1
SCHEMBL30582857 0.84 TRPM8 (0.69) TRPM8NPC1L3MBTL1
SCHEMBL2721605 0.84 TRPM8 (0.77) TRPM8NPC1L3MBTL1
SCHEMBL2720874 0.84 TRPM8 (0.69) TRPM8NPC1L3MBTL1
SCHEMBL2721610 0.84 TRPM8 (0.77) TRPM8NPC1L3MBTL1
SCHEMBL2720877 0.84 TRPM8 (0.69) TRPM8NPC1L3MBTL1
SCHEMBL2721442 0.84 TRPM8 (0.68) TRPM8NPC1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025132323-A1 COMPOSITIONS COMPRISING A SUNSCREEN ACTIVE AGENT DSM-FIRMENICH AG (CH) 2025-06-26 — — WO disclosed
EP-3470407-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2024-01-24 — — EP disclosed
EP-3478089-B1 PLATED YEAST FORMULATIONS FIRMENICH & CIE (CH) 2021-11-03 — — EP disclosed
US-11160894-B2 Perfume emanating device FIRMENICH SA (CH) 2021-11-02 — — US disclosed
US-11091734-B2 Plated yeast formulations FIRMENICH SA (CH) 2021-08-17 — — US disclosed
US-10953007-B2 Compounds useful as modulators of TRPM8 FIRMENICH INCORPORATED (US) 2021-03-23 — — US disclosed
EP-3478089-A1 PLATED YEAST FORMULATIONS Firmenich SA (CH) 2019-05-08 — — EP disclosed
EP-3470407-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2019-04-17 — — EP disclosed
EP-2635572-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-10-17 — — EP disclosed
US-20180289704-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2018-10-11 — — US disclosed
US-20180264156-A1 PERFUME EMANATING DEVICE FIRMENICH SA (CH) 2018-09-20 — — US disclosed
EP-3355944-A1 PERFUME EMANATING DEVICE Firmenich SA (CH) 2018-08-08 — — EP disclosed
US-10016418-B2 Compounds useful as modulators of TRPM8 Seaomyx, Inc. (US) 2018-07-10 — — US disclosed
WO-2018002331-A1 PLATED YEAST FORMULATIONS FIRMENICH SA (CH) 2018-01-04 — — WO disclosed
US-20160317532-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2016-11-03 — — US disclosed
US-9394287-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2016-07-19 — — US disclosed
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2013-12-05 — — US disclosed
EP-2635572-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2013-09-11 — — EP disclosed
WO-2012061698-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-09-13 — — WO disclosed
WO-2012061698-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-05-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160894-B2 Perfume emanating device DPM1, SURF4, FAAH2 TRPM8 151/4885MEN1 3360/4885USP2 1750/4885
US-10953007-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885MEN1 476/4885USP2 4713/4885
US-10016418-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885MEN1 476/4885USP2 4713/4885
US-20180264156-A1 PERFUME EMANATING DEVICE DPM1, SURF4, FAAH2 TRPM8 151/4885MEN1 3360/4885USP2 1750/4885
US-20160317532-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885MEN1 476/4885USP2 4713/4885
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885MEN1 476/4885USP2 4713/4885
US-20180289704-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885MEN1 476/4885USP2 4713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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