Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DUT | P33316 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722101 | 0.91 | DRD3 (0.43) | DRD3DRD2HRH4MEN1KMT2A | |
| SCHEMBL900249 | 0.91 | MAPT (0.42) | DRD3DRD2MAPTHRH4MEN1 | |
| SCHEMBL2720626 | 0.91 | DRD3 (0.41) | DRD3DRD2HRH4MEN1KMT2A | |
| SCHEMBL2721839 | 0.90 | DRD3 (0.43) | DRD3DRD2MEN1KMT2AKCNH2 | |
| SCHEMBL2722268 | 0.89 | DRD3 (0.42) | DRD3DRD2MAPTHRH4MEN1 | |
| SCHEMBL2719981 | 0.89 | PRMT5 (0.41) | DRD3DRD2KCNH2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2720512 | 0.89 | DRD3 (0.42) | DRD3DRD2MAPTMEN1POLB | |
| SCHEMBL2721632 | 0.89 | DRD3 (0.42) | DRD3DRD2HRH4MEN1KMT2A | |
| SCHEMBL2721765 | 0.88 | PDE10A (0.42) | DRD3DRD2HRH4MEN1KMT2A | |
| SCHEMBL2720352 | 0.88 | ALDH1A1 (0.44) | DRD3DRD2HRH4POLBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | disclosed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | disclosed |