Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721030 | 0.91 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 | |
| SCHEMBL900156 | 0.91 | PDE10A (0.39) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 | |
| SCHEMBL2721765 | 0.90 | PDE10A (0.42) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 | |
| SCHEMBL2719885 | 0.90 | HTR2B (0.44) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 | |
| SCHEMBL2720709 | 0.90 | KCNH2 (0.47) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 | |
| SCHEMBL900249 | 0.90 | MAPT (0.42) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 | |
| SCHEMBL2721839 | 0.89 | DRD3 (0.43) | ALDH1A1SMN1; SMN2DRD2DRD3KCNH2 | |
| SCHEMBL2721011 | 0.89 | PDE10A (0.41) | PDE10AHRH4 | |
| SCHEMBL2722268 | 0.88 | DRD3 (0.42) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 | |
| SCHEMBL2720206 | 0.88 | DRD3 (0.39) | ALDH1A1SMN1; SMN2HTTDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | disclosed |