Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720352 | 0.91 | ALDH1A1 (0.44) | PDE10AHRH4KCNH2DRD3SMN1; SMN2 | |
| SCHEMBL2721839 | 0.90 | DRD3 (0.43) | KCNH2DRD3HTR1ASMN1; SMN2KMT2A | |
| SCHEMBL2721765 | 0.90 | PDE10A (0.42) | PDE10AHRH4KCNH2DRD3MGLL | |
| SCHEMBL900249 | 0.89 | MAPT (0.42) | PDE10AHRH4KCNH2DRD3SMN1; SMN2 | |
| SCHEMBL2719981 | 0.88 | PRMT5 (0.41) | KCNH2DRD3HRH3SMN1; SMN2LMNA | |
| SCHEMBL2721011 | 0.88 | PDE10A (0.41) | PDE10AHRH4SLC6A2 | |
| SCHEMBL2720358 | 0.88 | HRH4 (0.45) | HRH4KCNH2DRD3CHRM2HTR1A | |
| SCHEMBL2723739 | 0.87 | VCP (0.40) | PDE10AHRH4KMT2AVCPMAPK1 | |
| SCHEMBL2722268 | 0.87 | DRD3 (0.42) | PDE10AHRH4KCNH2DRD3HTR1A | |
| SCHEMBL2720206 | 0.87 | DRD3 (0.39) | PDE10AHRH4KCNH2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | disclosed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | disclosed |